Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by the progressive loss of motor neurons, leading to paralysis and death within several years of onset.Although protein misfolding is a key feature of ALS, the upstream triggers of disease remain elusive.Recently, endoplasmic reticulum (ER) stress was Hand
BackgroundThe heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment.The sophisticated role of cancer stemness in mediating resistance to immune checkpoint inhibitors (ICIs) is still inadequately comprehended.MethodsGenome-scale CRISPR screening of RNA
People ascribe purposeful behaviour to the movements of artificial objects and social qualities to human body motion.We investigated how people associate simple motion cues with social categories.For a first rating-experiment we converted the body movements of speakers into stick-figure animations; for a second rating-experiment we used animations